LNK (SH2B3) Mouse Monoclonal Antibody [Clone ID: OTI2B11]

Specifications

Product Data
Clone Name	OTI2B11
Applications	FC, IF, WB
Recommend Dilution	WB 1:500, IF 1:100, FLOW 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human SH2B3 (NP_005466) produced in HEK293T cell.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.61 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	63 kDa
Gene Name	SH2B adaptor protein 3
Database Link	NP_005466 Entrez Gene 10019 Human UniProt ID Q9UQQ2
Background	This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
Synonyms	IDDM20; LNK
Reference Data
Protein Pathways	Neurotrophin signaling pathway

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