Desmin (DES) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4G1]

Specifications

Product Data
Clone Name	OTI4G1
Applications	FC, IHC, WB
Recommend Dilution	WB 1:200~500, IHC 1:150, FLOW 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human fragment corresponding to amino acids 104-391 of human DES (NP_001918) produced in E.coli.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	53.4 kDa
Gene Name	desmin
Database Link	NP_001918 Entrez Gene 13346 MouseEntrez Gene 64362 RatEntrez Gene 1674 Human UniProt ID P17661
Background	This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
Synonyms	CDCD3; CSM1; CSM2; LGMD1D; LGMD1E; LGMD2R
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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