NUMB Mouse Monoclonal Antibody [Clone ID: OTI1A7]

Specifications

Product Data
Clone Name	OTI1A7
Applications	FC, IF, WB
Recommend Dilution	WB 1:2000, IF 1:100, FLOW 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human NUMB (NP_003735) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.6 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	69.3 kDa
Gene Name	NUMB endocytic adaptor protein
Database Link	NP_003735 Entrez Gene 18222 MouseEntrez Gene 29419 RatEntrez Gene 8650 Human UniProt ID P49757
Background	The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
Synonyms	C14orf41; c14_5527; S171
Reference Data
Protein Pathways	Notch signaling pathway

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