BTK Mouse Monoclonal Antibody [Clone ID: OTI12D4]

Specifications

Product Data
Clone Name	OTI12D4
Applications	FC, IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:50, IF 1:100, Flow 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human BTK (NP_000052) produced in HEK293T cell.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	76.1 kDa
Gene Name	Bruton tyrosine kinase
Database Link	NP_000052 Entrez Gene 12229 MouseEntrez Gene 367901 RatEntrez Gene 695 Human UniProt ID Q06187
Background	The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes,and associated with a failure of Ig heavy chain rearrangement.
Synonyms	AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency

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