XRCC1 Mouse Monoclonal Antibody [Clone ID: OTI2F8]

Specifications

Product Data
Clone Name	OTI2F8
Applications	IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:50, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human XRCC1 (NP_006288) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.64 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	69.5 kDa
Gene Name	X-ray repair cross complementing 1
Database Link	NP_006288 Entrez Gene 22594 MouseEntrez Gene 84495 RatEntrez Gene 7515 Human UniProt ID P18887
Background	The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Synonyms	RCC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Base excision repair

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