MAN1 (LEMD3) Mouse Monoclonal Antibody [Clone ID: OTI4E1]

Specifications

Product Data
Clone Name	OTI4E1
Applications	IP, WB
Recommend Dilution	WB 1:1000, IF 1:100, Flow 1:100, IP 2-4ug/mg
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human LEMD3 (NP_055134) produced in HEK293T cell.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	100.0 kDa
Gene Name	LEM domain containing 3
Database Link	NP_055134 Entrez Gene 380664 MouseEntrez Gene 680066 RatEntrez Gene 23592 Human UniProt ID Q9Y2U8
Background	This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
Synonyms	MAN1
Reference Data
Protein Families	Transmembrane

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