Phospho-MTOR Rabbit Polyclonal Antibody

CAT#: TA420111

Phospho-mTOR-S2448 Rabbit mAb



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CNY 7,740.00


货期*
5周

规格
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB,1:500 - 1:1000
IHC-P,1:50 - 1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic phosphorylated peptide around S2448 of human mTOR.
Formulation Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 289kDa - Observed MW: 289kDa
Gene Name mechanistic target of rapamycin
Background The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene.
Synonyms FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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