Rabbit Monoclonal Antibody [Clone ID: P38G1]

Specifications

Product Data
Clone Name	P38G1
Applications	ELISA, FC
Reactivity	Human, Mouse
Modifications	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Host	Rabbit
Clonality	Monoclonal
Immunogen	The original antibody was generated by immunizing BALB/c mice with a mixture of transfected HEK 293 cells expressing human and mouse β-DAG.
Specificity	This antibody recognizes human and mouse beta dystroglycan (β-DAG). Beta-dystroglycan is a transmembrane protein that plays an important role in connecting the extracellular matrix to the cytoskeleton. It plays an important role in linking dystrophin to the laminin-binding alpha-dystroglycan. It acts as a cell adhesion receptor in both muscle and non-muscle tissues. It also functions in cell adhesion-mediated signaling and implicated in cell polarity. The binding specificity of this antibody to human and mouse beta dystroglycan expressed on the surface of CHO cells was confirmed using ELISA and flow cytometry. The binding affinity of the original IgG antibody to human beta dystroglycan was determined to be 941 pM. This antibody was used in combination with anti-Laminin antibody PL60B3 for the generation of a bispecific antibody (CN113651891).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Database Link	UniProt ID Q14118; Q62165
Synonyms	B-Dystroglycan; B Dystroglycan; Beta-DG; Beta-dystroglycan; BETA DAG; Dag1; Dystroglycan; Dystroglycan 1; Dystrophin-associated glycoprotein 1; β-DAG; β-dystroglycan; β dystroglycan
Reference Data

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