CD161 (KLRB1) Mouse Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:2000 IHC: 1:50~1:200
Reactivity	Rat
Host	Mouse
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids of Human CD161.
Specificity	CD161 (3F8) mAb detects endogenous levels of CD161 protein.
Isotype	IgG
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 25 kDa
Gene Name	killer cell lectin like receptor B1
Database Link	UniProt ID Q12918
Background	Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. T cells bearing natural killer receptors (NKRs) such as CD94 and CD161 are present in psoriasis. CD161 mediates NK cell activation and functions as an activating receptor. CD161 is a prototypic marker of NK cells, although it is also found on a subset of CD8+ T cells. The expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector T cells that are expanded in vivo after antigenic activation leading to extensive proliferation. The transcription, mRNA accumulation, and surface expression of CD161, a molecule involved in triggering cytotoxicity, is specifically upregulated by IL-12.
Synonyms	C-type lectin domain family 5 member B; CD161; HNKR-P1a; Killer cell lectin-like receptor subfamily B member 1; Natural killer cell surface protein P1A; NKR-P1A
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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