Ku70 (XRCC6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from human Ku-70 around the phosphorylation site of S5.
Specificity	Ku-70 (phospho-S5) polyclonal antibody detects endogenous levels of Ku-70 protein around the phosphorylation site of S5.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 70 kDa
Gene Name	X-ray repair complementing defective repair in Chinese hamster cells 6
Database Link	Entrez Gene 2547 Human UniProt ID P12956
Background	The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 (or p86), which is also known by the synonym Ku-80 (or p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation.
Synonyms	5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; Chinese hamster cells 6; CTC75; CTCBF; CTC box-binding factor 75 kDa subunit; DNA repair protein XRCC6; G22P1; Ku70; Lupus Ku autoantigen protein p70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in; X-ray repair cross-complementing protein 6; XRCC6
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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