hnRNP Q (SYNCRIP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 241-290 of Human hnRNP Q.
Specificity	hnRNP Q (E268) polyclonal antibody detects endogenous levels of hnRNP Q protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 65-82 kDa
Gene Name	synaptotagmin binding cytoplasmic RNA interacting protein
Database Link	Entrez Gene 10492 Human UniProt ID O60506
Background	Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.
Synonyms	Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; HNRPQ; NS1-associated protein 1; NSAP1; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; SYNCRIP
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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