TAK1 (MAP3K7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB:1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human Tak1 around the phosphorylation site of Threonine 184.
Specificity	Tak1 (phospho-T184) polyclonal antibody detects endogenous levels of Tak1 protein when phosphorylated at Thr184.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~70, 82 kDa
Gene Name	mitogen-activated protein kinase kinase kinase 7
Database Link	Entrez Gene 6885 Human UniProt ID O43318
Background	Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine/threonine residues and that is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFß-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFß stimulation.
Synonyms	MAP3K7; Mitogen-activated protein kinase kinase kinase 7; TAK1; TGF-beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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