ROR alpha (RORA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:5000~1:10000
Reactivity	Pig
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human RORA.
Specificity	RORA polyclonal antibody detects endogenous levels of RORA protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 58 kDa
Gene Name	RAR related orphan receptor A
Database Link	UniProt ID P35398
Background	Retinoids are metabolites of vitamin A (retinol) and represent an important class of signaling molecule during vertebrate development and tissue differentiation. A large group of nuclear transcription factors, including vitamin D3 receptor (VDR), thyroid hormone receptor (TR), RAR, RXR and ecdysone receptor, have a high affinity for retinoic acids and are members of the steroid receptor superfamily. This family acts by directly associating with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. RORα is a member of the steroid receptor superfamily and is classified as an “orphan receptor” due to the lack of a defined ligand. Two isoforms of RORα have been described and are designated RORα1 and RORα2. RORα, also referred to as RZR, binds DNA as a monomer at consensus RORα response elements (ROREs).
Synonyms	NR1F1, RZRA; Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha; RORA
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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