splicing factor 1 (SF1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000 IHC: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human SF1.
Specificity	SF1 polyclonal antibody detects endogenous levels of SF1 protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 75 kDa
Gene Name	splicing factor 1
Database Link	Entrez Gene 7536 Human UniProt ID Q15637
Background	Mammalian splicing factor 1 (designated SF1, zinc finger protein 162, ZFM1,CW17R and mammalian branch point binding protein [mBBP]) specificallyrecognizes the seven-nucleotide branch point sequence located at 3' splicesites and participates in the assembly of early spliceosomal complexes.Splicing factor 1 functions as a transcriptional repressor and may control bothproliferation and expression of pro-inflammatory gene products in smoothmuscle cells. In addition, cytokine-induced downregulation of splicing factor 1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases. The structure of splicing factor 1 contains a nuclear transport domain, a metal binding motif, and glutamine- and proline-rich regions.Human splicing factor 1 also exists as several different isoforms, H1-isoformand Bo-isoform, produced by alternative splicing events. The human splicingfactor 1 gene is located on chromosome 11 close to the gene encoding Menin,the gene responsible for multiple endocrine neoplasia-type 1 (MEN1).
Synonyms	BBP; Mammalian branch point-binding protein; mBBP; SF1; Splicing factor 1; Transcription factor ZFM1; ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162; ZNF162
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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