CD6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Rat, Mouse, Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CD6.
Specificity	CD6 polyclonal antibody detects endogenous levels of CD6 protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 95 kDa
Gene Name	CD6 molecule
Database Link	Entrez Gene 923 Human UniProt ID P30203
Background	Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166.Contributes to signaling cascades triggered by activation of the TCR/CD3 complex.Functions as costimulatory molecule; promotes T-cell activation and proliferation.Contributes to the formation and maturation of the immunological synapse.Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria.LPS binding leads to the activation of signaling cascades and down-stream MAP kinases.Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Synonyms	CD6; Soluble CD6; T-cell differentiation antigen CD6; T12; TP120
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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