ICAM5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human ICAM-5.
Specificity	ICAM-5 polyclonal antibody detects endogenous levels of ICAM-5 protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 180 kDa
Gene Name	intercellular adhesion molecule 5
Database Link	Entrez Gene 7087 Human UniProt ID Q9UMF0
Background	Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to playimportant, yet separate, roles in embryogenesis and development. The intracellular adhesion molecule-1 (ICAM-1), also referred to as CD54, is an integral membrane protein of the immunoglobulin superfamily and recognizes the β2α1 and β2αM integrins. ICAM-2 functions as a ligand for lymphocyte functionassociated antigen-1 (LFA-1) and is involved in leukocyte adhesion. ICAM-3 is highly expressed on the surface of human eosinophils, and when bound to ligand may inhibit eosinophil inflammatory responses and survival. ICAM-4, also known as LW glycoprotein, interacts with the integrins αLβ2, αMβ2, α4β1, the αV family and αIIbβ3, and selective binding to different integrins may be relevant to the pathology in a number of red blood cell associated diseases. Lastly, ICAM-5, expressed on telencephalic neurons, binds CD11a/CD18 and thus may act as an adhesion molecule for leukocyte binding in the central nervous system.
Synonyms	ICAM-5; ICAM5; Intercellular adhesion molecule 5; Telencephalin; TLCN; TLN
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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