DR5 (TNFRSF10B) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CD262.
Specificity	CD262 polyclonal antibody detects endogenous levels of CD262protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 55 kDa
Gene Name	tumor necrosis factor receptor superfamily member 10b
Database Link	Entrez Gene 8795 Human UniProt ID O14763
Background	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Synonyms	Death receptor 5; DR5, KILLER, TRAILR2, TRICK2, ZTNFR9; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL-R2; TRAIL receptor 2; Tumor necrosis factor receptor superfamily member 10B; UNQ160/PRO186
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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