Anti-CSF1R antibody(DM108), Rabbit mAb

Specifications

Product Data
Clone Name	DM108
Applications	ELISA, FC
Recommend Dilution	ELISA 1:5000-10000 Flow Cyt 1:100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Isotype	IgG
Formulation	1XPBS
Concentration	Lot specific
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Background	The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
Synonyms	CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Reference Data

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