c Fos (FOS) Mouse Monoclonal Antibody [Clone ID: 2H2]

Specifications

Product Data
Clone Name	2H2
Applications	ICC, IHC, WB
Recommend Dilution	WB: 1:2000 ICC: 1:1000
Reactivity	Bovine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full length human c-FOS expressed in and purified from E. Coli.
Specificity	Specific for endogenous levels of the ~50 kDa c-FOS protein.
Isotype	IgG1
Formulation	PBS + 50% glycerol and 5 mM NaN3
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	50
Gene Name	Fos proto-oncogene, AP-1 transcription factor subunit
Database Link	Entrez Gene 2353 Human UniProt ID P01100
Background	c-FOS is a member of the FOS transcription factor family which forms dimers with c-JUN to produce the Activator Protein 1 (AP-1) complex which plays a key role in critical cellular processes such as cell proliferation, differentiation and apoptosis (Chiu et al., 1988). c-FOS expression has been demonstrated to be a useful marker of neuronal activation as it is rapidly induced following various stimuli (Hoffman et al., 1993). Additionally, c-FOS has been shown to be overexpressed in a variety of malignant tumor types (Milde-Langosch 2005).
Synonyms	AP-1; C-FOS; G0S7
Note	Protein G purified culture supernatant.
Reference Data

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