TRIM56 Rabbit Monoclonal Antibody [Clone ID: R02-8A3]

Specifications

Product Data
Clone Name	R02-8A3
Applications	IF, WB
Recommend Dilution	WB: 1/2000-1/10000 ICC/IF: 1/50-1/100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human TRIM56
Isotype	IgG
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 82 kDa; Observed MW: 82 kDa
Gene Name	tripartite motif containing 56
Database Link	Entrez Gene 81844 Human UniProt ID Q9BRZ2
Background	Swiss-Prot Acc.Q9BRZ2.E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Synonyms	DKFZp667O116; FLJ35608; RNF109
Reference Data

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