TRIM23 Rabbit Monoclonal Antibody [Clone ID: R09-4K7]

Specifications

Product Data
Clone Name	R09-4K7
Applications	WB
Recommend Dilution	WB: 1/2000-1/10000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human TRIM23
Isotype	IgG
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 64 kDa; Observed MW: 64 kDa
Gene Name	tripartite motif containing 23
Database Link	Entrez Gene 373 Human UniProt ID P36406
Background	Swiss-Prot Acc.P36406.Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
Synonyms	ARD1; ARFD1; RNF46
Reference Data

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