TCF7L2 Rabbit Monoclonal Antibody [Clone ID: R09-1D1]

Specifications

Product Data
Clone Name	R09-1D1
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/50 IP: 1/20
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human TCF-4
Isotype	IgG
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 68 kDa; Observed MW: 68 kDa
Gene Name	transcription factor 7 like 2
Database Link	Entrez Gene 6934 Human UniProt ID Q9NQB0
Background	Swiss-Prot Acc.Q9NQB0.Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
Synonyms	hTCF-4; TCF-4; TCF4
Reference Data

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