Sonic Hedgehog (SHH) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	IHC-p: 1/50-1/200 WB: 1/500-1/2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthesized peptide derived from human Shh
Isotype	IgG
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Observed MW (kDa):40
Gene Name	sonic hedgehog
Database Link	Entrez Gene 6469 Human UniProt ID Q15465
Background	Swiss-Prot Acc.Q15465.Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity . Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN . Both activities occur in the reticulum endoplasmic . Once cleaved, ShhC is degraded in the endoplasmic reticulum .
Synonyms	HHG-1; HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS
Reference Data

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