Cyclophilin F (PPIF) Rabbit Monoclonal Antibody [Clone ID: R02-6I9]

Specifications

Product Data
Clone Name	R02-6I9
Applications	IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/500
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Cyclophilin F
Isotype	IgG
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 22 kDa; Observed MW: 18 kDa
Gene Name	peptidylprolyl isomerase F
Database Link	Entrez Gene 10105 Human UniProt ID P30405
Background	Swiss-Prot Acc.P30405.PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Synonyms	Cyp-D; CYP3; FLJ90798; hCyP3; MGC117207; PPIase; rotamase
Reference Data

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