PI 3 Kinase p85 alpha (PIK3R1) Mouse Monoclonal Antibody [Clone ID: 1C8-2H4-9D9]

Specifications

Product Data
Clone Name	1C8-2H4-9D9
Applications	IHC, WB
Recommend Dilution	WB: 1/1000-2000 IHC: 1/100-200
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant protein expressed in E.coli.
Isotype	IgG1
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	85kDa
Gene Name	phosphoinositide-3-kinase regulatory subunit 1
Database Link	Entrez Gene 5295 Human UniProt ID P27986
Background	Swiss-Prot Acc.P27986.Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Synonyms	GRB1; p85; p85-ALPHA; PI3K
Reference Data

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