LC3B (MAP1LC3B) Mouse Monoclonal Antibody [Clone ID: 8H6-6D10-3A4]

Specifications

Product Data
Clone Name	8H6-6D10-3A4
Applications	IHC
Recommend Dilution	IHC: 1/100-200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant protein expressed in E.coli.
Isotype	IgG1
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	14,16kDa
Gene Name	microtubule associated protein 1 light chain 3 beta
Database Link	Entrez Gene 81631 Human UniProt ID Q9GZQ8
Background	Swiss-Prot Acc.Q9GZQ8.Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Synonyms	LC3B; MAP1A/1BLC3; MAP1ALC3
Reference Data

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