KIF7 Mouse Monoclonal Antibody [Clone ID: 2A7-10B8-9A9]

Specifications

Product Data
Clone Name	2A7-10B8-9A9
Applications	IF, IHC
Recommend Dilution	IHC: 1/200 IF: 1/50-200
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic Peptide of Kif 7
Isotype	IgG1
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Gene Name	kinesin family member 7
Database Link	Entrez Gene 374654 Human UniProt ID Q2M1P5
Background	Swiss-Prot Acc.Q2M1P5.Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .
Synonyms	EQYK340; MGC120653; MGC138476; MGC138478; UNQ340
Reference Data

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