IRE1 (ERN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1/500-1/2000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human Phospho-IRE1 (S724) (Phosphorylated)
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	110kDa
Gene Name	endoplasmic reticulum to nucleus signaling 1
Database Link	Entrez Gene 2081 Human UniProt ID O75460
Background	Swiss-Prot Acc.O75460.Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Synonyms	FLJ30999; hIRE1p; IRE1; Ire1-alpha; IRE1a; IRE1P; MGC163277; MGC163279
Reference Data

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