CD3G Rabbit Monoclonal Antibody [Clone ID: R07-1C8]

CAT#: TA383935S

CD3G Rabbit monoclonal Antibody

Size: 20 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 20 ul

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Specifications

Product Data
Clone Name R07-1C8
Applications IHC, IP, WB
Recommend Dilution WB: 1/2000-1/10000
IHC: 1/50-1/200
IP: 1/20-1/50
Reactivity Human
Host Rabbit
Clonality Monoclonal
Immunogen A synthetic peptide of human CD3G
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size Calculated MW: 21 kDa; Observed MW: 21 kDa
Gene Name CD3g molecule
Background Swiss-Prot Acc.P09693.Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Synonyms CD3-GAMMA; FLJ17620; FLJ17664; FLJ79544; FLJ94613; MGC138597; T3G
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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