CD10 (MME) Mouse Monoclonal Antibody [Clone ID: 7C7-1G5-10E3]

Specifications

Product Data
Clone Name	7C7-1G5-10E3
Applications	IHC
Recommend Dilution	IHC: 1/200
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide conjugated to KLH.
Isotype	IgG1
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Gene Name	membrane metallo-endopeptidase
Database Link	Entrez Gene 4311 Human UniProt ID P08473
Background	Swiss-Prot Acc.P08473.Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Synonyms	atriopeptidase; CALLA; CD10; DKFZp686O16152; Enkephalinase; EPN; MGC126681; MGC126707; NEP; neprilysin
Reference Data

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