CD40 Rabbit Polyclonal Antibody

CAT#: TA374456

CD40 Rabbit polyclonal Antibody



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB,1:500 - 1:2000
IHC,1:50 - 1:100
Reactivity Human, Mouse, Rat
Modifications Unmodified
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide of human CD40
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 22kDa/30kDa
Gene Name CD40 molecule
Background This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms Bp50; CDW40; MGC9013; p50; TNFRSF5
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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