EXD2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse brain tissue and Human cerebrum tissue lysates IHC: 40-200 Positive control: Human tonsil Predicted cell location: Cytoplasm or Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human EXD2
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	70 kDa
Gene Name	exonuclease 3'-5' domain containing 2
Database Link	Entrez Gene 55218 Human UniProt ID Q9NVH0
Background	Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.
Synonyms	C14orf114; DKFZp781A0133; DKFZp781L15100; EXDL2; FLJ10738; OTTHUMP00000205813; OTTHUMP00000205816; OTTHUMP00000205817; OTTHUMP00000205818
Reference Data

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