EFHD2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: A549 cell lysate
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human EFHD2
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	27 kDa
Gene Name	EF-hand domain family member D2
Database Link	Entrez Gene 79180 Human UniProt ID Q96C19
Background	EFHD2 is a calcium-binding adaptor protein associated with pathologically aggregated tau in Alzheimer disease brain and in a mouse model of frontotemporal dementia. EFHD2 has cell type-specific functions, including modulation of intracellular calcium responses, actin dynamics, and microtubule transport. May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Synonyms	MGC4342; Swiprosin-1; SWS1
Reference Data

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