DR4 (TNFRSF10A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: PC-3 and LOVO cell lysates IHC: 25-50 Positive control: Human colorectal cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human TNFRSF10A
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	50 kDa
Gene Name	tumor necrosis factor receptor superfamily member 10a
Database Link	Entrez Gene 8797 Human UniProt ID O00220
Background	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Synonyms	APO2; CD261; DR4; MGC9365; TRAIL-R1; TRAILR-1; TRAILR1
Reference Data

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