Complement C7 (C7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: HUVEC cell lysate
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human C7
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	94 kDa
Gene Name	complement component 7
Database Link	Entrez Gene 730 Human UniProt ID P10643
Background	The complement cascade is a multi-protein system that functions to clear pathogens from an infected host. Part of the innate (unchanging) immune system, the complement cascade consists of proteins and inactive zymogens that are present in blood and are stimulated by one of several triggers. Once stimulated, the cascade relays amplified responses throughout the body, ultimately activating the cell-killing membrane attack complex which can insert itself into the cell membrane and cause the cell to lyse. C7 (complement component 7) is an 843 amino acid secreted protein that participates in the formation of membrane attack complex (MAC), a complex that forms pores in the plasma membrane of target cells for innate and adaptive immune responses. As a membrane anchor, C7 exists as a monomer or dimer and can form multimeric rosettes with C5β. C7 defects are the cause of component C7 deficiency (C7D), characterized by recurrent bacterial infections caused by Neisseria meningitidis.
Synonyms	C7
Reference Data

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