SFXN1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: Human fetal liver tissue and Human cerebrum tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human SFXN1
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	36 kDa
Gene Name	sideroflexin 1
Database Link	Entrez Gene 94081 Human UniProt ID Q9H9B4
Background	The sideroflexin (SFXN) family is comprised of SFXN1, SFXN2, SFXN3, SFXN4 and SFXN5. SFXN1, also designated tricarboxylate carrier protein TCC, is the most highly characterized family member. The ubiquitously expressed SFXN1 protein resides as an integral protein of the mitochondrial inner membrane. It functions as an essential component of the shuttle system that transports mitochondrial acetyl-CoA into the cytosol, where lipogenesis occurs. The SFXN1 gene is mutated in flexed-tail (f/f) mice, which display axial skeletal abnormalities and a transient embryonic and neonatal anemia characterized by pathologic intramitochondiral iron deposits in erythrocytes. Therefore, SFXN1 is also thought to facilitate the transport of a component required for iron utilization into mitochondria. All SFXN family members show expression in pancreatic islet cells. SFXN5 displays a citrate transport activity and is primarily expressed in brain.
Synonyms	FLJ12876; TCC
Reference Data

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