PXR (NR1I2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1000-5000 WB positive control: Rat liver tissue lysate
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human NR1I2
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	50 kDa
Gene Name	nuclear receptor subfamily 1 group I member 2
Database Link	Entrez Gene 8856 Human UniProt ID O75469
Background	This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Synonyms	BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Reference Data

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