EGFR Mouse Monoclonal Antibody [Clone ID: EGFR.113]

Specifications

Product Data
Clone Name	EGFR.113
Applications	IHC
Recommend Dilution	1:20
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic fusion protein corresponding to the external domain of the epidermal growth factor receptor molecule
Specificity	External domain of the human epidermal growth factor receptor
Isotype	IgG2a
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	epidermal growth factor receptor
Database Link	Entrez Gene 1956 Human UniProt ID P00533
Background	Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells, for example, in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.
Synonyms	ERBB; ERBB1; HER1; mENA; PIG61
Reference Data

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