Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: 15C8]

Specifications

Product Data
Clone Name	15C8
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to the epidermal growth factor homology domain of the human CD141 molecule
Specificity	Human thrombomodulin, also known as fetomodulin, endothelial anticoagulant protein, glycoprotein P112 and CD141
Isotype	IgG1
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	thrombomodulin
Database Link	Entrez Gene 7056 Human UniProt ID P07204
Background	Thrombomodulin is a transmembrane glycoprotein of 75 kD which can accelerate the activation of protein C. Activated protein C functions as an anticoagulant by combining with protein S to inactivate factors Va and VIIIa of the blood coagulation pathway and by binding thrombin. Several factors regulate thrombomodulin expression. Downregulation of thrombomodulin may be induced by the cytokine interleukin-1, tumor necrosis factor and endotoxin. Agents which increase cyclic AMP such as forskolin may upregulate thrombomodulin activity in endothelial cells. Thrombomodulin has been identified within a number of normal tissues. These include the lining cells of arteries, veins, capillaries and the lymphatics as well as mesothelial cells, meningeal lining cells, synovial cells, syncytiotrophoblasts, megakaryocytes and platelets.
Synonyms	AHUS6; CD141; fetomodulin; THRM; thrombomodulin; TM
Reference Data

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