Lymphocyte Activation Gene 3 (LAG3) Mouse Monoclonal Antibody [Clone ID: 2G8]

Specifications

Product Data
Clone Name	2G8
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	ELISA start at 0.25 ug/mL. WB start at 0.25 ug/mL. ICC start at 1 ug/mL. IF start at 10 ug/mL. IHC start at 5 ug/mL. FC start at 1 ug/mL.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	LAG-3 antibody was raised against the extracellular domain of human LAG-3
Isotype	IgG1, kappa
Formulation	LAG-3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	LAG-3 Antibody is supplied as protein A purified IgG1.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 55 kDa; Observed: 60, 70, 80 kDa
Gene Name	lymphocyte activating 3
Database Link	NP_002277 Entrez Gene 3902 Human UniProt ID P18627
Background	The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity ,negatively regulating T-cell function and homeostasis.It is expressed in B, T, and NK cells, monocytes, and dendritic cells,and acts to regulate T cell expansion.LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.
Synonyms	CD223; FDC; LAG-3
Reference Data

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