PD-L1 (CD274) Mouse Monoclonal Antibody [Clone ID: 6H10]

CAT#: TA355068

Mouse Monoclonal Anti-PD-L1 Antibody [6H10]



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CNY 6,861.00


货期*
5周

规格
    • 100 ug

经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

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Transient overexpression lysate of PD-L1 / CD274 molecule (PD-L1 / CD274)
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Clone Name 6H10
Applications IF, IHC, WB
Recommend Dilution WB: 0.5-1µg/mL. IHC starting at 2-5µg/mL.IF start at 5µg/mL.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen PD-L1 antibody was raised against the extracellular domain of human PD-L1.
Formulation PD-L1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification PD-L1 Antibody is supplied as protein A purified IgG1.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 32 kDa; Observed: 45 kDa
Gene Name CD274 molecule
Background PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).
Synonyms B7-H; B7-H1; B7H1; MGC142294; MGC142296; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Note PD-L1 antibody can be used for detection of PD-L1 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2 - 5 µg/mL. For immunofluorescence start at 5 µg/mL.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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