Zinc transporter 8 (SLC30A8) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1-2µg/mL.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8.
Isotype	IgG
Formulation	SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SLC30A8 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 35, 41 kDa; Observed: 35, 41 kDa
Gene Name	solute carrier family 30 member 8
Database Link	NP_776250 Entrez Gene 169026 Human UniProt ID Q8IWU4
Background	SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in ?-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).
Synonyms	ZnT-8; ZNT8
Note	SLC30A8 antibody can be used for Western blot at 1 - 2 µg/mL.
Reference Data

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