HOOK3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1-2µg/mL.IHC: 10µg/ml.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	HOOK3 antibody was raised against a 19 amino acid peptide from near the amino terminus of human HOOK3. The immunogen is located within amino acids 210 - 260 of HOOK3.
Isotype	IgG
Formulation	HOOK3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	HOOK3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 79 kDa; Observed: 77 kDa
Gene Name	hook microtubule-tethering protein 3
Database Link	NP_115786 Entrez Gene 84376 Human UniProt ID Q86VS8
Background	The HOOK proteins (HOOK1, HOOK2 and HOOK3) comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules mediating the spatial organization of diverse membrane-trafficking systems; their more divergent C-terminal domains mediate binding to organelles (1,2). HOOK3 exists as a homodimer and participates in defining the architecture and localization of the Golgi complex through its central coiled-coil domain (3). HOOK3 may regulate clearance of endocytosed receptors such as MSR1 (3,4).
Synonyms	FLJ31058; hHK3; HK3
Note	HOOK3 antibody can be used for the detection of HOOK3 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry at 10 µg/ml.
Reference Data

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