NANOG Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The Synthetic peptide corresponding to the N-term of human Nanog (29aa-50aa).
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42 kDa
Gene Name	Nanog homeobox
Database Link	NP_001284627 Entrez Gene 79923 Human UniProt ID Q9H9S0
Background	Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES cells through activation of Stat3. However, LIF/Stat3 is dispensable for maintenance of ICM and human ES cells, suggesting that the pathway is not fundamental for pluripotency. Nanog is a homeodomain containing transcription factor that is essential for the maintenance of pluripotency and self renewal in embryonic stem cells and ICM. Nanog expression is controlled by a network of factors including Sox2 and the key pluripotency regulator Oct4 and other transcription factors such as KLF4, c-Myc and Lin28.
Synonyms	FLJ12581; FLJ40451; hNanog
Reference Data
Protein Families	Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Stem cell - Pluripotency

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.