BLK Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to N-term of human Blk protein. This sequence is identical to mouse and rat.
Isotype	IgG
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	56 kDa
Gene Name	BLK proto-oncogene, Src family tyrosine kinase
Database Link	NP_001706 Entrez Gene 640 Human UniProt ID P51451
Background	The Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transducer signals that are involved in the control of a variety of cellular process, including proliferation, differentiation, motility, and adhesion. Blk is a 505 aa protein, known as a nonreceptor tyrosine-kinase of the Src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucos and enhances the expression of several pancreatic beta-cell transcription factors. Blk protein is expressed exclusively by B lymphocytes.
Synonyms	MODY11
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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