ERAB (HSD17B10) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	WB 0.5-5 µg/ml ELISA N/A IP 2-5 µg/ml IHC 1-5 µg/ml FC Not tested
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to aa 100-116 of human ERAB protein.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	27 kDa
Gene Name	hydroxysteroid (17-beta) dehydrogenase 10
Database Link	NP_001032900 Entrez Gene 3028 Human UniProt ID Q99714
Background	Mutations in several genes associated with early onset Alzheimer’s result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer’s disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer’s disease.
Synonyms	17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

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