Tuberin (TSC2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: A172 cells IHC: 10-50 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human TSC2
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	201 kDa
Gene Name	tuberous sclerosis 2
Database Link	NP_001070651 Entrez Gene 22084 MouseEntrez Gene 24855 RatEntrez Gene 7249 Human UniProt ID P49815
Background	Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms	LAM; PPP1R160; TSC4
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Insulin signaling pathway, mTOR signaling pathway, p53 signaling pathway

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