SIGLEC8 Rabbit Polyclonal Antibody
CAT＃: TA351667S
Rabbit Polyclonal Anti-SIGLEC8 Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 3080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SIGLEC8 |
| Isotype | IgG |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | sialic acid binding Ig like lectin 8 |
| Database Link | |
| Background | Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]). |
| Synonyms | SAF2; SIGLEC-8; SIGLEC8L |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
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