ALOX15 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Hela cell lysate IHC: 50-200 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human ALOX15
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	75 kDa
Gene Name	arachidonate 15-lipoxygenase
Database Link	NP_001131 Entrez Gene 11687 MouseEntrez Gene 81639 RatEntrez Gene 246 Human UniProt ID P16050
Background	Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene. The ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53. The ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.
Synonyms	12-LOX; 15-LOX-1; 15LOX-1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Linoleic acid metabolism, Metabolic pathways

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