Myosin heavy chain 8 (MYH8) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MYH8 antibody was raised against a 19 amino acid peptide near the amino terminus of human MYH8.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	MYH8 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 213 kDa; Observed: 220 kDa
Gene Name	myosin, heavy chain 8, skeletal muscle, perinatal
Database Link	NP_002463 Entrez Gene 4626 Human UniProt ID P13535
Background	Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1). MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal) is a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction (2,3). This gene is predominantly expressed in fetal skeletal muscle. MYH8 is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations (3). A mutation in this gene results in trismus-pseudocamptodactyly syndrome (4).
Synonyms	Myosin heavy chain 8, Myosin-8, Myosin heavy chain skeletal muscle perinatal, MyHC-perinatal, MyHC-peri, MyHC-pn, gtMHC-F
Reference Data

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